IBDase
Mucosal protease and their inhibitors in inflammatory bowel disease: From etiopathogenetic insight to innovative therapy
Scientific publications 2010
Hedrich, J.; Lottaz, D., Meyer, K.; Yiallouros, I.; Jahnen-Dechent, W.; Stöcker, W. and Becker-Pauly, C. (2010). Fetuin-A and Cystatin C are Endogenous Inhibitors of human Meprin Metalloproteases. Biochemistry, 49 (39), 8599–8607.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20806899
Kronenberg, D., Bruns, B.C., Moali, C., Vadon-Le Goff, S., Sterchi, E.E., Traupe, H., Böhm, M., Hulmes, D.J.S., Stöcker, W. and Becker-Pauly, C. (2010). Processing of procollagen III by meprins: new players in extracellular matrix assembly? Journal of Investigative Dermatology, 130(12):2727-35.
Pubmed: http://www.nature.com/jid/journal/v130/n12/pdf/jid2010202a.pdf
Ohler, A., Debela, M., Magdolen, V. and Becker-Pauly, C. (2010). Meprin Metalloproteases are activated specifically by KLK 4,5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. Biological Chemistry, 391(4), 455-460.
Link: http://www.ncbi.nlm.nih.gov/pubmed/20128684
Schütte, A., Stöcker, W. and Becker-Pauly, C. (2010). Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of meprin alpha 2 (PLoS ONE, 21;5(1):e8835).
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20098618
F.A. Carvalho, N. Barnich, A. Sivignon, C. Darcha, C.H.F. Chan, C.P. Stanners and A. Darfeuille-Michaud (2009). Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. The Journal of Experimental Medicine 206 (10): 2179-2189.
download pdf
P. Lapaquette, A.-L.Glasser, A. Huett, R. J. Xavier and A. Darfeuille-Michaud (2010). Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cellular Microbiology 12(1): 99-113. download pdf
S. Miquel, L. Claret, R. Bonnet, I. Dorboz, N. Barnich and A. Darfeuille-Michaud (2010). Role of decreased levels of Fis histone-like protein in Crohn's disease-associated AIEC LF82 bacteria interacting with intestinal epithelial cells. Journal of Bacteriology, 192:1832-1843.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20118249
Scientific publications 2009
M.E. Johansson, K.A. Thomsson and G.C. Hansson (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Journal of Proteome Research 8(7): 3549-3557. Pubmed
S. Banerjee, B. Oneda, L. M. Yap, D. Jewell, G. Matters, L. Fitzpatrick, F. Seibold, E. Sterchi, T. Ahmad, D. Lottaz and J. Bond (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology 2: 220-231. download pdf
Note: Research leading to the above publication had been conducted mainly before the onset of the IBDase project.
Hedrich, J.; Lottaz, D., Meyer, K.; Yiallouros, I.; Jahnen-Dechent, W.; Stöcker, W. and Becker-Pauly, C. (2010). Fetuin-A and Cystatin C are Endogenous Inhibitors of human Meprin Metalloproteases. Biochemistry, 49 (39), 8599–8607.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20806899
Kronenberg, D., Bruns, B.C., Moali, C., Vadon-Le Goff, S., Sterchi, E.E., Traupe, H., Böhm, M., Hulmes, D.J.S., Stöcker, W. and Becker-Pauly, C. (2010). Processing of procollagen III by meprins: new players in extracellular matrix assembly? Journal of Investigative Dermatology, 130(12):2727-35.
Pubmed: http://www.nature.com/jid/journal/v130/n12/pdf/jid2010202a.pdf
Ohler, A., Debela, M., Magdolen, V. and Becker-Pauly, C. (2010). Meprin Metalloproteases are activated specifically by KLK 4,5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. Biological Chemistry, 391(4), 455-460.
Link: http://www.ncbi.nlm.nih.gov/pubmed/20128684
Schütte, A., Stöcker, W. and Becker-Pauly, C. (2010). Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of meprin alpha 2 (PLoS ONE, 21;5(1):e8835).
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20098618
F.A. Carvalho, N. Barnich, A. Sivignon, C. Darcha, C.H.F. Chan, C.P. Stanners and A. Darfeuille-Michaud (2009). Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. The Journal of Experimental Medicine 206 (10): 2179-2189.
download pdf
P. Lapaquette, A.-L.Glasser, A. Huett, R. J. Xavier and A. Darfeuille-Michaud (2010). Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cellular Microbiology 12(1): 99-113. download pdf
S. Miquel, L. Claret, R. Bonnet, I. Dorboz, N. Barnich and A. Darfeuille-Michaud (2010). Role of decreased levels of Fis histone-like protein in Crohn's disease-associated AIEC LF82 bacteria interacting with intestinal epithelial cells. Journal of Bacteriology, 192:1832-1843.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20118249
Scientific publications 2009
M.E. Johansson, K.A. Thomsson and G.C. Hansson (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Journal of Proteome Research 8(7): 3549-3557. Pubmed
S. Banerjee, B. Oneda, L. M. Yap, D. Jewell, G. Matters, L. Fitzpatrick, F. Seibold, E. Sterchi, T. Ahmad, D. Lottaz and J. Bond (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology 2: 220-231. download pdf
Note: Research leading to the above publication had been conducted mainly before the onset of the IBDase project.
Flyer
The project has produced a brochure to raise awareness of IBDase among clinicians, patients, and the interested public. If you are interested to receive copies, also for further dissemination, please contact the project office (follow the link at the base of the page). download flyer
The project has produced a brochure to raise awareness of IBDase among clinicians, patients, and the interested public. If you are interested to receive copies, also for further dissemination, please contact the project office (follow the link at the base of the page). download flyer